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Bachelor of Science
Master of Arts
Doctor of Philosophy
My research is concerned with determining the mechanisms by which aging and disease-related proteins result in brain degeneration, and how nutritional intervention can prevent the damage associated with "normal" aging or neurodenegerative disease states such as dementia. I am currently focusing on two main projects, both of which fit under the global topic of neurodegeneration. The first project investigates the difference between how "good" fats (like those from walnuts) and "bad" fats (like those found in fried foods) can affect the brain and brain cell models. The second main focus of my research involves the neurodegenerative protein HIV-Tat, which is a likely mediator of pathology and loss of functioning associated with HIV dementia. The future goal for this project is to determine how this single neurotoxic HIV protein disrupts the function and health of neurons and glial cells.
Carey AN, Fisher DR, Joseph JA, Shukitt-Hale S. (2012) The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. Nutritional Neuroscience. (in press)
Carey AN, Poulose SM, Shukitt-Hale B. (2012) The beneficial effects of tree nuts on the aging brain. Nutrition and Aging, 1:55-67.
Poulose, SM, Fisher DR, Larson J, Bielinkski DF, Carey AN, Schauss AG, Shukitt-Hale B. (2012) Attenuation of inflammatory stress signaling by acai berry (Euterpe oleracea mart) extracts in BV-2 mouse microglial cells. Journal of Agriculture and Food Chemistry, 60:1084-1093.
Carey AN, Sypek EI, Singh HD, Kaufman MJ, McLaughlin JP. (2012) Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse. Behavioral Brain Research, 229:48-56.
Shukitt-Hale B, Kalt W, Carey AN, Vinquist-Tymchuk M, McDonald J, and Joseph JA. (2009) Plum juice, but not dried plum powder, is effective in mitigating cognitive deficits in aged rats. Nutrition, 25:567-573.
Shukitt-Hale B, Carey A, Simon L, Mark DA, Joseph JA. (2006) Effects of Concord grape juice on cognitive and motor deficits in aging. Nutrition: The International Journal of Applied and Basic Nutritional Sciences, 3:295-302.
Shukitt-Hale B, Carey AN, Joseph JA. (2005) Phytochemicals in foods and beverages: Effects on the central nervous system. In Lieberman HR, Kanarek RB, Prasad C. eds. Nutritional Neuroscience. CRC Press, Taylor & Francis Group, LLC Boca Raton, FL, 393-404.
Joseph JA, Fisher DR, Carey AN. (2004) Fruit extracts antagonize amyloid-beta- or dopamine- induced deficits in calcium flux in M1-transfected COS-7 cells. Journal of Alzheimer's Disease, 6:403-411.
Carey AN. (2011) Superfruits: Brain food, Supply Side West Superfruit Update: Science, Consumers and the State of the Category Workshop, Las Vegas, Nevada.
Carey AN. (2011) Keynote Address, Food for Thought: Nutrition and Brain Aging. Sigma Xi Delta Chapter Induction Ceremony. Boston, Massachusetts.
Carey AN, Fisher DR, Bielinski DF, Shukitt-Hale B. (2011) Anti-inflammatory effects of walnut-associated fatty acids in BV-2 microglia. American Aging Association 40th Annual Meeting. Raleigh, North Carolina. (Runner-up for the Paul F. Glenn Award)
Carey AN, Sypek EI, Liu X, Kaufman MJ, McLaughlin JP. (2010) HIV-Tat protein mediation of NeuroAIDS central nervous system pathology and behavioral disinhibition. Society for Neuroscience Annual Meeting. San Diego, California.
Carey AN, Sypek EI, McLaughlin JP. (2009) Neuropathology induced by HIV-Tat protein is associated with lasting impairments in learning and memory. Society for Neuroscience Annual Meeting. Chicago, Illinois.
Carey AN. (2008) The effects of HIV-Tat protein on brain and behavior. The GWIS Alpha Omega Chapter Award Winning Science Reception. Boston, Massachusetts.